Mouse Monoclonal Antibody (Mab)

CCRK抗体;Cyclin-dependent kinase 20; CDK-activating kinase p42; CAK-kinase p42; Cell cycle-related kinase; Cell division protein kinase 20; Cyclin-dependent protein kinase H; Cyclin-kinase-activating kinase p42; CDK20; CCRK; CDCH

Mouse

Purified His-tagged CCRK protein was used to produced this monoclonal antibody.

Human

WB~~1:1000

Predicted molecular weight: 39kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Monoclonal Antibody

885CT27.1.1

IgG1

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Signal Transduction

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue ‘Thr-160’.

Nucleus. Cytoplasm. Cell projection, cilium

Q8IZL9

Liu Y., et al. J. Biol. Chem. 279:4507-4514(2004).
Wang L.Y., et al. Oncogene 31:2907-2918(2012).
Qiu H., et al. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
Ota T., et al. Nat. Genet. 36:40-45(2004).
Humphray S.J., et al. Nature 429:369-374(2004).