BRD4884 is an HDAC inhibitor with IC₅₀ values of 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively.¹ It possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min versus 20 min).¹ BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration.¹

≥98%

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1.Wagner, F.F.,Zhang, Y.-L.,Fass, D.M., et al. Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers. Chem.Sci. 6(1), 804-815 (2015).