PF-06882961 TrisCAS号： 2230198-03-3分子式： C35H41FN6O7分子量： 676.7描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
PF-06882961 Tris is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist.
|
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 可溶性/溶解性 |
DMSO:10 mM
|
| 生物活性 | |
| In vitro(体外研究) |
Biological in-vitro testing revealed favorable ADME and pharmacological profiles for the best PF-06882961 Tris[1].
|
| In vivo(体内研究) |
PF-06882961 Tris shows mild to moderate damage to the heart, moderate to severe effects on the thymus gland (which helps with managing infection), mild to moderate stomach ulcers at the highest dose level given in the rat[2].
|