YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder contraction in rats by inhibiting bladder pressurization. YM-58790 free base inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

mAChR3:15 nM (Ki), mAChR2:260 nM (Ki), mAChR1:28 nM (Ki)

YM-58790 free base (compound 18b) (0-1 μM) exerts a potent inhibitory effect on urinary bladder contraction while having minimal impact on bradycardia. In vitro, YM-58790 demonstrates selective antagonism between urinary bladder contraction and salivary secretion.[1]

YM-58790 free base (3 mg/kg, i.v.) exhibits no impact on oxotremorine-induced tremor in mice.[1]
YM-58790 free base (6.0 mg/kg; i.v.) exhibits limited M1 and M2 antagonistic effects in vivo on McN-A343-induced pressor response in pithed rats. However, it demonstrates robust efficacy in M3 antagonism, with an ED30 value of 0.36 mg/kg and an ID50 value of 2.4 mg/kg.[1]
YM-58790 free base demonstrates robust inhibitory activity on bladder pressure during reflexly-evoked rhythmic contractions in rats.[1]