Tyrphostin AG 879CAS号： 148741-30-4分子式： C18H24N2OS分子量： 316.46描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
Tyrphostin AG 879有效抑制HER2/ErbB2，IC50为1 μM，作用于ErbB2比作用于PDGFR和EGFR选择性高100到500倍。 |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
AG 879
|
| 外观 |
黄色粉末
|
| 可溶性/溶解性 |
Ethanol ：7.9 mg/mL (25 mM)
DMSO ：31.7 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 |
HER2-Neu ,Trk
|
| In vitro(体外研究) |
AG879 inhibits growth of FET6αS26X cells in a concentration-dependent manner. AG879(10 nM) blocks the activation of PAK1 and suppresses RAS-induced malignant transformation of NIH 3T3 cells. AG879( AG 879 dose-dependently reduce MCF-7 cell numbers and show already a significant effect at 0.4 mM through inhibiting DNA synthesis and mitotic. AG 879( AG879(20 μM) dramatically decreases proliferation with a variable increase in apoptosis in Cell lines from human leiomyosarcoma (HTB-114, HTB-115, HTB-88), rhabdomyosarcoma (HTB-82, TE-671), prostatic adenocarcinoma (PC-3), acute promyelocytic leukemia (HL-60) and histiocytic lymphoma (U-937).
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| In vivo(体内研究) |
AG879(2 mg) induces a decrease in cancer growth in athymic NOD/SCID mice grafted with HTB-114 or HL-60. AG 879(20 mg/kg) treatment keeps 50% of mice JPolutely free of RAS-induced sarcomas, and dramatically reduces the size of the growing sarcomas in the nude mice carrying v-Ha-RAS transformed NIH 3T3 cells.
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分子结构图
