JNJ 28871063 hydrochlorideCAS号： 944341-54-2分子式： C24H27CIN6O3•HCl分子量： 519.42描述应用纯度储存/保存方法形态别名折射率IC50可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC50 = 60 – 168 nM). JNJ 28871063 hydrochloride is an inhibitor of ErbB-4 and Neu.
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| 应用 |
A potent inhibitor of ErbB receptors
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| 纯度 |
>97%
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| 储存/保存方法 |
Store at 4° C
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride
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| 折射率 |
n20D ~1.64 (Predicted)
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| IC50 |
ErbB4: IC50 = 21 nM; EGFR : IC50 = 22 nM; ErbB2 : IC50 = 38 nM; EGF-induced EFGR: IC50 = 107 nM; Basal HER2: IC50 = 223 nM
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| 可溶性/溶解性 |
Soluble in DMSO (50 mM).
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| MDL |
MFCD12828762
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| PubChem CID |
17747413
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