Thyroid Hormone Receptor Antagonist, 1-850CAS号： 251310-57-3分子式： C21H20F3N5O4分子量： 463.42描述应用纯度储存/保存方法形态别名可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
Thyroid Hormone Receptor Antagonist, 1-850 is a cell-permeable hydrazinyl-carboxamide compound which acts as a selective and high-affinity thyroid receptor antagonist (IC50 = 1.5 μM in HeLa cells). It is shown to block T3- (L-triiodothyronine) mediated interaction of TRα with nuclear receptor coactivator (NRC) as well as prevent the stimulation of gene expression. It exerts no effect on the retinoic acid receptor α (RARα) activity.
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| 应用 |
A selective and high-affinity thyroid hormone receptor (TR) antagonist
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at-20℃，3 years.
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
TR Antagonist; 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
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| 可溶性/溶解性 |
Soluble in DMSO (5 mg/ml).
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| MDL |
MFCD06411459
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| PubChem CID |
2765122
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分子结构图
