MSC2360844CAS号： 1305267-37-1分子式： C26H27FN4O5S分子量： 526.58描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:90 mg/mL (170.91mM)
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| 生物活性 | |
| 靶点 |
PI3Kδ:145 nM
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| In vitro(体外研究) |
MSC2360844 inhibits B cell proliferation in a concentration-dependent manner with an IC50 of 48?nM. MSC2360844 blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells[1].
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| In vivo(体内研究) |
in a murine SLE model，MSC2360844 ameliorates disease manifestations [1].
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