RG2833CAS号： 1215493-56-3分子式： C20H25N3O2分子量： 339.43描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
RG2833 is a brain-penetrant inhibitor of HDAC with IC50 values of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
RG 2833, RG FP109, RG-2833, RGFP-109
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO 68 mg/mL (200.33 mM)
Ethanol 10 mg/mL (29.46 mM) |
| 生物活性 | |
| 靶点 |
HDAC3 ,HDAC1
|
| In vitro(体外研究) |
RGFP109 dose-dependently upregulates frataxin mRNA and protein levels in cultures of unstimulated peripheral blood mononuclear cells (PBMC) obtained from FRDA patients.
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| In vivo(体内研究) |
RG2833 (150 mg/kg) corrects frataxin deficiency and increases histone acetylation in the brain and heart of KIKI mice without acute toxicity signs. RGFP109 ameliorates the disease phenotype of a Friedreich ataxia mouse model. RGFP109 (30 mg/kg p.o.) also alleviates established l-DOPA-induced dyskinesia.
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分子结构图
