MK-8325

MK-8325CAS号: 1334314-19-0分子式: C43H54Cl2F2N8O6Si分子量: 915.93描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)

产品描述
描述
MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailability in in vitro and in vivo assays and has a favorable overall ADME profile.
纯度
98%
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性
DMSO:9.16 mg/mL (10 mM)
生物活性
In vitro(体外研究)
MK-8325 (7 μM) demonstrates no cell toxicity with a CC50 > 25 mM against Huh-7 replicon cells in a standard MTS assay.[1]
In vivo(体内研究)
In vivo assays showed MK-8325 to be orally bioavailable with pharmacokinetics suitable for once-daily dosing in patients and good overall ADME profiles.[1]