PA-824是一种抗肺结核药，作用于tuberculosis（肺结核），MIC低于2.8 μM。

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Pretomanid；(S)-PA 824

Ethanol ：16mg/mL(44.53mM)
DMSO ：72mg/ml(200.41 mM)

tuberculosis

In vitro, PA-824 exhibits the high activity against multidrug-resistant clinical isolates from Asia (India and South Korea) and from throughout the United States (MIC A recent study shows that single-nucleotide polymorphisms of PA-824 resistance genes (fgd1 and ddn ) don’t significantly affect the PA-824 MICs (≤ 0.25 μg/ml).

In the rapid tuberculosis mouse model, PA-824 shows significant anti-microbial activity in a dose-dependent manner: at 50 mg/kg, PA-824 in MC produces a more than 1-log reduction of the CFU in the lungs; at 100 mg/kg it produces about a 2-log reduction, and at 300 mg/kg it produces a 3-log reduction. Furthermore, long-term treatment of PA-824 at 100 mg/kg in cyclodextrin/lecithin also leads to the reduction of the bacterial load below 500 CFU in the lungs and spleen. PA-824 exhibits time-dependent anti-microbial activity in a murine model of tuberculosis with a maximal observed bactericidal effect of 0.1 log CFU/day over 24 days.

PA-824 exhibits time-dependent activity in a murine model of tuberculosis.
Ahmad Z,et al. Antimicrob Agents Chemother. 2011 Jan;55(1):239-45. PMID: 20937781䔸Żᩄ族痛셌Ų族痛셌ŲItem褐Count๏
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