L-817,818CAS号： 217480-27-8分子式： C33H36N4O3分子量： 536.67描述应用储存/保存方法形态密度沸点折射率IC50PK值Ki 数据可溶性/溶解性MDL
| 产品描述 | |
| 描述 |
L-817,818 is a potent and selective non-peptide SSTR5 (somatostatin subtype-5) receptor agonist. Inhibits growth hormone release from rat pituitary cells and insulin release from mouse pancreatic islets in vitro.
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| 应用 |
A non-peptide somatostatin subtype-5 receptor agonist
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| 储存/保存方法 |
Store at -20° C
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| 形态 |
Solid
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| 基本信息 | |
| 密度 |
1.24 g/cm3 (Predicted)
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| 沸点 |
827.86° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.67 (Predicted)
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| IC50 |
Pancreatic islets: EC5050 = 0.3 nM (mouse); Pituitary cells: EC5050 = 3.1 nM (rat)
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| PK值 |
pKb: 10.42 (Predicted)
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| Ki 数据 |
Sst1 receptor: Ki= 0.4 nM (human); Sst1 receptor: Ki= 3.3 nM (human); Sst2 receptor: Ki= 52 nM (human); Sst3 receptor: Ki= 64 nM (human); Sst4 receptor: Ki= 82 nM (human)
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| 可溶性/溶解性 |
Soluble in DMSO (100 mM).
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| MDL |
MFCD09971065
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