NP118809CAS号： 41332-24-5分子式： C32H32N2O分子量： 460.61描述纯度储存/保存方法别名外观可溶性/溶解性参考文献
| 产品描述 | |
| 描述 |
NP-118809 (39-1B4) is a potent N-type calcium channel blockers (IC50= 0.11 uM) which has good selectivity over L-type calcium channels. NP-118809 exhibites increased N-type channel blockade (IC50=0.11 uM) and is 111-fold more selective for N-type channels (L-type calcium channel IC50=12.2 uM). NP118809 further exhibits a number of favorable preclinical characteristics as they relate to overall pharmacokinetics and minimal off-target activity including the hERG potassium channel. |
| 纯度 |
>95%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
39-1B4, NP-118809
|
| 外观 |
固体粉末
|
| 可溶性/溶解性 |
10 mM in DMSO
|
| 参考文献 | |
| 参考文献 |
Scaffold-based design and synthesis of potent N-type calcium channel blockers.
Zamponi GW,et al. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. PMID: 198154 䔸Żᩄ 族痛 |
分子结构图
