GSK2807 TrifluoroacetateCAS号： 2245255-66-5分子式： C21H33F3N8O7分子量： 566.53描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM.
|
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
GSK2807三氟乙酸盐
|
| 可溶性/溶解性 |
H2O : ≥ 50 mg/mL (88.26 mM)
|
| 生物活性 | |
| 靶点 |
SMYD3
|
| In vitro(体外研究) |
A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively).
|
分子结构图
