U-47931E (Item No. 20530) is an analytical reference standard that is structurally categorized as an opioid. It has been characterized as a selective µ-opioid receptor agonist, based on the ability of the antagonist β-funaltrexamine to block U-47931E-mediated decrease in urine output in water-loaded rats.¹ U-47931E has antinociceptive activity comparable to codeine (Item No. ISO60140) in mouse abdominal constriction and rat paw pressure tests.² This product is intended for research and forensic applications.

≥98%

Store at -20℃

Bromadoline;

1.Hayes, A.G.,Skingle, M. and Tyers, M.B. Evaluation of the receptor selectivities of opioid drugs by investigating the block of their effect on urine output by beta-funaltrexamine. J. Pharmacol. Exp. Ther. 240(3), 984-988 (1987).

2.Hayes, A.G.,Sheehan, M.J. and Tyers, M.B. Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to μ- and κ-opioid receptor agonists. Br. J. Pharmacol. 91(4), 823-832 (1987).