GBR 12783 diHydrochlorideCAS号: 67469-75-4分子式: C28H34Cl2N2O分子量: 485.49描述纯度储存/保存方法可溶性/溶解性In vivo(体内研究)
产品描述 | |
描述 |
GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor. GBR 12783 dihydrochloride inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
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纯度 |
98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
可溶性/溶解性 |
DMSO:45 mg/mL (92.69 mM)
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生物活性 | |
In vivo(体内研究) |
GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].
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