CNX-774CAS号： 1202759-32-7分子式： C26H22FN7O3分子量： 499.5描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
CNX-774 is an orally active, irreversible and selective BTK inhibitor, with an IC50 of < 1 nM. CNX-774 specifically targets Cysteine 481 of Btk for covalent modification.
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
CNX774
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| 可溶性/溶解性 |
DMSO : ≥ 45 mg/mL (90.09 mM)
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| 生物活性 | |
| 靶点 |
BTK
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| In vitro(体外研究) |
In cellular assays, CNX-774 demonstrates potent inhibitory activity towards BTK with IC50 of 1-10 nM by targeting Cys-481 residue within the ATP binding site of the enzyme.
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分子结构图
