INT-767CAS号： 1000403-03-1分子式： C25H43NaO6S分子量： 494.66描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
INT-767是一种有效的FXR和TGR5激动剂 (平均EC50为30 nM和630 nM)。 |
| 纯度 |
>98.0%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 可溶性/溶解性 |
DMSO : ≥ 205.5 mg/mL
|
| 生物活性 | |
| 靶点 |
FXR
|
| In vitro(体外研究) |
INT-767 does not show cytotoxic effects in HepG2 cells, does not inhibit cytochrome P450 enzymes, does not inhibit the human ether-a-go-go-related gene potassium channel.is highly stable to phase I and II enzymatic modifications.
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| In vivo(体内研究) |
INT-767 decreases triglyceride levels and plasma total cholesterol in db/m and db/db mice.
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分子结构图
