IACS-010759CAS号： 1570496-34-2分子式： C25H25F3N6O4S分子量： 562.57描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
IACS-010759 is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
IACS-10759
|
| 外观 |
powder
|
| 可溶性/溶解性 |
DMSO ：27 mg/mL (47.99 mM)
|
| 生物活性 | |
| 靶点 |
oxidative phosphorylation,OXPHOS
|
| In vitro(体外研究) |
IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations.
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| In vivo(体内研究) |
IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models.
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分子结构图
