AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

97%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:1.5 mg/mL (2.8 mM)

TEC:1317 nM, IRR:840 nM, ALK:420 nM, Brk:843 nM, MNK2:228 nM, MLK1:88 nM, ErbB4:195 nM, IGF-1R:1.6 μM, Flt4:1784 nM, PYK2:2288 nM, BLK:977 nM, Ack1:156 nM, Ins R:1256 nM, FAK:995 nM, FLT3:302 nM, FES:449 nM

AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).