URB-754 was originally described as a potent and selective inhibitor of MAG lipase which selectively raises levels of 2-arachidonoylglycerol (2AG). Subsequent studies have shown that that URB-754 does not inhibit recombinant MAG Lipase and that the original activity was due to a contaminant, bis(methylthio)mercurane, in another commercial source. URB-754 is an inhibitor of FAAH.

A potent and selective inhibitor of MAG lipase which selectively raises levels of 2AG

≥98%

Store at -20° C

Solid

~1.2 g/cm³ (Predicted)

≥ 260° C (lit.)

~434.0° C at 760 mmHg (Predicted)

n²⁰_D 1.63

monoacylglycerol lipase (MAGL): IC₅₀ = 200 nM (rat); brain fatty acyl amide hydrolase (FAAH) : IC₅₀ = 32 µM (rat); central cannabinoid (CB1) receptor : IC₅₀ = 3.8 µM (rat)

Soluble in DMSO (15 mg/mL), and DMF. Insoluble in water.

848487