四丁酸核黄素酯CAS号: 752-56-7分子式: C33H44N4O10分子量: 656.72描述纯度储存/保存方法密度熔点折射率可溶性/溶解性MDLPubChem CIDBeilstein 注册EC号码In vitro(体外研究)In vivo(体内研究)
产品描述 | |
描述 |
Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.
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纯度 |
≥98%
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储存/保存方法 |
Store at room temperature
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基本信息 | |
密度 |
1.30 g/cm3 (Predicted)
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熔点 |
146° C
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折射率 |
n20D 1.59 (Predicted)
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可溶性/溶解性 |
Soluble in ethanol, acetone, chloroform, and diethyl ether (slightly). Insoluble in hexane, and water.
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MDL |
MFCD00059691
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PubChem CID |
5065
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Beilstein 注册 |
604729
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EC号码 |
212-034-5
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生物活性 | |
In vitro(体外研究) |
Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is JPtracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction.
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In vivo(体内研究) |
Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevated serum lipid. Feeding of Riboflavin Tetrabutyrate results in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration results in an increased beta-oxidation of fatty acid in the liver.
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分子结构图