BD750CAS号： 892686-59-8分子式：
C14H13N3OS
分子量： 271.34描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
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| 外观 |
white to light brown powder
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| 可溶性/溶解性 |
DMSO : 10 mg/mL
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| 生物活性 | |
| 靶点 |
JAK3；STAT5
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| In vitro(体外研究) |
BD750 inhibits human T cell proliferation stimulated either by anti-CD3/anti-CD28 mAbs or by alloantigen in a dose-dependent manner with IC50 values of 1.1 ± 0.2 μM and 1.3 ± 0.2 μM respectively. BD750 also inhibits ConA, PMA/ionomycine or alloantigen-induced mouse T cell proliferation and PHA or PMA/ionomycine-induced human T cell proliferation. BD750 (5 or 20 μM) inhibits the LPS-induced JAK-STAT5 signaling in DC.
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| In vivo(体内研究) |
BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune encephalitis (EAE) in mice.
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分子结构图
