Hydroxychloroquine SulfateCAS号： 747-36-4分子式： C18H28ClN3O5S分子量： 433.95描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa.
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
硫酸羟氯喹；HCQ sulfate
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| 外观 |
白色结晶性粉末
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| 可溶性/溶解性 |
water : 43.4 mg/mL (100 mM)
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| 生物活性 | |
| 靶点 |
Parasite
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| In vitro(体外研究) |
Hydroxychloroquine sulfate is a synthetic antimalarial drug derived from 4-aminoquinoline; it has been used for several decades for the treatment of some rheumatic diseases such as rheumatoid arthritis (RA). Five micromolar Hydroxychloroquine sulfate or chloroquine also has no measurable effect on intracellular pH, although these concentrations can inhibit TLR9 or 7 signaling induced by DNA or RNA ligands.
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| In vivo(体内研究) |
Hydroxychloroquine sulfate is prescribed for the treatment of lupus, and both Hydroxychloroquine sulfate and its analog chloroquine inhibit TLR7 and 9 signaling.
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| 参考文献 | |
| 参考文献 |
[1] Ramser B, et al.J Invest Dermatol, 2009,129(10):2419-26. [2] Lee HO, et al. PLoS One. 2015, 10(7): e0131464. [3] Bourke L, et al. PLoS One. 2015, 10(12):e0143771. [4] Marta Mosca, et al. 2013 ACR/ARHP Annual Meeting. [5] Lamphier M, et al. Mol Pharmacol. 2014, 85(3):429-440. |
分子结构图
