ABBV-744CAS号： 2138861-99-9 分子式： C28H30FN3O4分子量： 491.55描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS. |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
CPD1639
|
| 外观 |
powder
|
| 可溶性/溶解性 |
DMSO : 37.14 mg/mL (75.56 mM; Need ultrasonic)
|
| 生物活性 | |
| 靶点 |
BDII
|
| In vitro(体外研究) |
ABBV-744 is a highly BDII-selective BET bromodomain inhibitor, used in the research of inflammatory diseases, cancer, and AIDS.
|
| In vivo(体内研究) |
In vivo, doses of ABBV-744 at fractions of its maximum tolerated dose (MTD) induces tumor growth inhibition in AML and prostate cancer xenograft models that were comparable to those observed with ABBV-075 when dosed at its MTD.
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分子结构图
