SB-742457CAS号： 607742-69-8分子式： C19H19N3O2S分子量： 353.12描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
SB-742457(RVT-101) is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
SB 742457，RVT 101，SB742457，RVT101
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO：78 mg/mL (220.68 mM)
Ethanol：2 mg/mL (5.65 mM) |
| 生物活性 | |
| 靶点 |
5-HT6
|
| In vitro(体外研究) |
SB-742457 is a selective 5-HT6 receptor antagonist with cognition, memory, and learning-enhancing effects. SB-742457 is a novel cognitive enhancing agent for Alzheimer’s disease. SB-742457 is a potential agent added to stablize donepezil treatment in subjects with mild-to-moderate Alzheimer’s disease.
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| In vivo(体内研究) |
SB-742457 is a potent and selective 5-HT6 receptor antagonist that is shown to reverse a scopolamine induced learning deficit in the novel object recognition test and to enhance performance in a water maze task by aged rats.
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分子结构图
