GW806742XCAS号： 579515-63-2分子式： C25H22F3N7O4S分子量： 573.55描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
GW806742X is a Mixed Lineage Kinase Domain-Like (MLKL) inhibitor which binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and anti-necroptosis activity. GW806742X has activity against VEGFR2.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO : ≥ 125 mg/mL (217.94 mM)
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| 生物活性 | |
| 靶点 |
MLKL
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| In vitro(体外研究) |
GW806742X (0.1-10000 nM) rescues 50% of wild-type mouse dermal fibroblasts (MDFs) from TSQ-induced necroptosis with an IC50< 50 nM when 1 ng/mL TNF is used. GW806742X (1 μM) retards MLKL translocation to the membrane.
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分子结构图
