This is amino acids 721 to 770 fragment of the amyloid precursor protein resulting from the g-secretase cleavage of the C-terminus of beta-amyloid precursor protein (APP) at Leu720-Val721. This peptide is also known as CTF50-99. The mutation at Leu723 (L723P) causes familial Alzheimer’s disease.

≥ 95%

-20°C

Gu, Y., et al.J. Biol. Chem. 276, 35235 (2001); Kwok, J. et al.Ann. Neurol. 47, 249 (2000).