UK-371804 hydrochlorideCAS号： 256476-36-5分子式： C14H16ClN5O4S.HCl分子量： 422.29描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
UK-371804 HCl
|
| 外观 |
white to beige powder
|
| 可溶性/溶解性 |
DMSO ：50 mg/mL (118.40 mM)
|
| 生物活性 | |
| 靶点 |
uPA
|
| In vitro(体外研究) |
UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM).
|
| In vivo(体内研究) |
in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters.
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分子结构图
