NNC 711CAS号： 145645-62-1分子式： C21H22N2O3•HCl分子量： 386.88描述应用纯度储存/保存方法形态别名熔点沸点IC50PK值Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
NNC 711 is a potent and selective inhibitor of GABA uptake by GABA T-1( (IC50 values are 0.04, 171, 1700 and 622 μM for hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1 respectively). GABA transporters belong to the solute carrier family 6 (SLC6) and are sodium- and chloride-dependent members that mediate the rapid removal of GABA. NNC 711 also exhibits cognition-enhancing activity.
|
| 应用 |
A potent and selective inhibitor of GABA T-1
|
| 纯度 |
≥99%
|
| 储存/保存方法 |
Desiccate at 4° C
|
| 形态 |
Solid
|
| 基本信息 | |
| 别名 |
NO-711 hydrochloride; 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy] ethyl]-3-pyridinecarboxylic acid hydrochloride
|
| 熔点 |
204-206° C
|
| 沸点 |
541.2° C at 760 mmHg (Predicted)
|
| IC50 |
HGAT-1: IC50 = 0.04 µM ; RGAT-2: IC50 = 171 µM ; HGAT-3 : IC50 = 1700 µM ; HBGT-1: IC50 = 622 µM
|
| PK值 |
pKa: 3.56 (Predicted), pKb: 7.76 (Predicted)
|
| Ki 数据 |
GABA transporter 1: Ki= 47 nM (Rattus norvegicus)
|
| 可溶性/溶解性 |
Soluble in water (≥10 mg/mL) at 60° C, ethanol (10 mM), and DMSO (100 mM).
|
| MDL |
MFCD00153853
|
| PubChem CID |
123738
|