GSK2269557 is an inhibitor of PI3Kδ (pK_i = 9.9) that is >1,000-fold selective for PI3Kδ over PI3Kα, β, and γ isoforms.¹ It is reported to be active in a brown Norway rat acute ovalbumin-induced allergic asthma model of Th2-driven lung inflammation (ED₅₀ = 67 µg/kg).¹

≥98%

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1.Down, K.,Amour, A.,Baldwin, I.R., et al. Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase δ for the treatment of respiratory disease. J. Med. Chem. 58(18), 7381-7399 (2015).