AGI-6780CAS号： 1432660-47-3分子式： C21H18F3N3O3S2分子量： 481.5描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2-R140Q (IC50=23 nM).
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
AGI 6780; AGI6780
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO 96 mg/mL (199.37 mM)
Ethanol 96 mg/mL (199.37 mM) |
| 生物活性 | |
| 靶点 |
IDH2 R140Q mutant
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| In vitro(体外研究) |
AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples.
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分子结构图
