SF1670CAS号： 345630-40-2分子式： C19H17NO3分子量： 307.34描述纯度储存/保存方法外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
SF1670是一种高度有效且专一的PTEN的抑制剂，其IC50 为 2 μM。 |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 外观 |
Red-violet solid
|
| 可溶性/溶解性 |
DMSO ：30.7 mg/mL (100 mM)
|
| 生物活性 | |
| 靶点 |
PTEN
|
| In vitro(体外研究) |
SF1670 shows potent cytotoxicity in HBEC, PC-3, H1299 cells with IC50 of 5 μM, 10 μM, 44 μM, respectively. In a mouse aortic ring matrigel angiogenesis model, SF1670 stimulates the angiogenic processes. SF1670 augments chemoattractant-elicited PtdIns(3,4,5)P3 signaling in neutrophils and enhances neutrophil functions.
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| In vivo(体内研究) |
Pretreatment of SF1670 (500 nM i.v.) augments bacteria-killing capability in neutropenic mice in both peritonitis and bacterial pneumonia, and decreases the mortality of neutropenia-related pneumonia.
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分子结构图
