BRD6688 is an HDAC inhibitor with IC₅₀ values of 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively.¹ It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1 (381 min versus 65 min).¹ BRD6688 crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration.¹

≥98%

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1.Wagner, F.F.,Zhang, Y.-L.,Fass, D.M., et al. Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers. Chem.Sci. 6(1), 804-815 (2015).