SU-6668CAS号: 210644-62-5分子式: C18H18N2O3 分子量: 310.4描述应用纯度储存/保存方法形态可溶性/溶解性PubChem CID
产品描述 | |
描述 |
PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
|
应用 |
A potent ATP-competitive inhibitor against tyrosine kinases
|
纯度 |
>97%
|
储存/保存方法 |
Store at 4° C
|
形态 |
Solid
|
基本信息 | |
可溶性/溶解性 |
Soluble in DMSO
|
PubChem CID |
5329099
|