SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:90.0 mg/mL (284.5 mM)

COX-2:26 nM

SC57666 exhibits potent inhibition of COX2 (IC50 of 3.2±0.8 nM) in CHO cells stably transfected with human COX isozymes, showing a selectivity of 1000-fold or greater over COX1 (IC50=6000±1900 nM) [1].

In the adjuvant-induced arthritis model, SC57666 exhibits oral activity with an ED50 of 1.7 mpk. When administered orally at a dose of 600 mpk, SC57666 does not cause gastric lesions in mice after 5 hours. Similarly, no intestinal damage is observed in rats after 72 hours when administered orally at a dose of 200 mpk [2].