AG-636CAS号： 1623416-31-8分子式： C21H17N3O2分子量： 343.38描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:31.25 mg/mL (91.01 mM)
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| 生物活性 | |
| 靶点 |
DHODH:17 nM
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| In vitro(体外研究) |
AG-636, in cancer cell lines of hematologic versus solid tumor origin.?Differential AG-636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model
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| In vivo(体内研究) |
AG-636 (10-100 mg/kg ;?oral gavage;?twice daily;?for 14 days) treatment results in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model
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