Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation.¹ AR420626 is a selective agonist of FFAR3 (GPR41; IC₅₀ = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM.² At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.³

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1.Inoue, D.,Tsujimoto, G. and Kimura, I. Regulation of energy homeostasis by GPR41. Front.Endocrinol.(Lausanne) 5, 1-3 (2014).

2.Engelstoft, M.S.,Park, W.m.,Sakata, I., et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol.Metab. 2(4), 376-392 (2013).

3.Nohr, M.K.,Pedersen, M.H.,Gille, A., et al. GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology 154(10), 3552-3564 (2013).