BMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:95 mg/mL (262.91 mM)

human FPR1:2800 nM (EC50), mouse FPR2:3.4 nM (EC50), human FPR2:0.41 nM (EC50)

BMS-986235 inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, thereby promoting resolution of inflammation[1].

In male C57BL/6 mice, BMS-986235 (0.3 mg/kg; p.o.) attenuates left ventricle and global cardiac remodeling after left anterior descending and reduces infarct length by 39% relative to the vehicle. BMS-986235 (1 mg/kg; p.o.) shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/L•h, and 24%, respectively[1].