GSK8612CAS号： 2361659-62-1分子式： C17H17BrF3N7O2S分子量： 520.33描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
GSK 8612
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| 外观 |
Beige solid
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| 可溶性/溶解性 |
DMSO :100 mg/mL (192.19 mM)
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| 生物活性 | |
| 靶点 |
TBK1
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| In vitro(体外研究) |
In cellular assays, GSK8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 was able to inhibit secretion of interferon-beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.
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分子结构图
