CGP 78608 HydrochlorideCAS号： 1135278-54-4分子式： C11H14BrClN3O5P分子量： 414.58描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:37.4 mg/mL (90.0 mM)
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| 生物活性 | |
| 靶点 |
NMDA receptor:6 nM
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| In vitro(体外研究) |
CGP 78608 hydrochloride reduces ammonia-dependent cGMP synthesis and relieves ammonia neurotoxicity[2]. CGP-78608 hydrochloride reduces glycine sensitivity of GluN1 and GluN3A receptors[3].
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| In vivo(体内研究) |
CGP-78608 (i.p.) exhibits anticonvulsant effects in the electroshock-induced convulsions assay in mice[1].
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