Purified Mouse Monoclonal Antibody (Mab)

MITF抗体;Microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; bHLHe32; MITF; BHLHE32

Mouse

This MITF antibody is generated from a mouse immunized with a recombinant protein of human MITF.

Human, Mouse, Rat

WB~~1:2000

Predicted molecular weight: 59kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Monoclonal Antibody

1607CT834.207.47

IgG1,k

Maintain refrigerated at 2-8°C for up to 2 weeks. For long time storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Immunology

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5′- CACGTG-3′) found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Nucleus.

O75030

Amae S.,et al.Biochem. Biophys. Res. Commun. 247:710-715(1998).
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Wang Y.,et al.BMC Med. 8:14-14(2010).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).