SER-601 is a potent and selective peripheral cannabinoid (CB₂) receptor agonist based on a quinolone-3-carboxylic acid core structure with 190-fold selectivity for CB₂ over the central CB₁ receptor (K_is = 6.3 and 1,220 nM, respectively).^1,2 At 3 mg/kg, SER-601 has analgesic effects in a formalin-induced nocifensive study in mice without cannabis-like behavioral effects due to its low affinity for CB₁.^1,2 This product is intended for forensic and research applications.

≥98%

Store at -20℃

1.Pasquini, S.,Botta, L.,Semeraro, T., et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo. Journal of Medicinal Chemistry 51, 5075-5084 (2008).

2.Pasquini, S.,Ligresti, A.,Mugnaini, C., et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands. Journal of Medicinal Chemistry 53, 5915-5928 (2012).