Jnj 16259685CAS号： 409345-29-5分子式： C20H23NO3分子量： 325.4描述应用纯度储存/保存方法形态密度沸点折射率IC50PK值Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
JNJ 16259685 is a sub-nanomolar potent, non-competitive mGluR-1 antagonist (Ki=0.34nM). Inhibits glutamate-induced Ca2+ response at the human mGluR-1 (IC50=0.55nM). Selective over mGluR-5 (>400-fold). Displays no activity at mGluR-2, mGluR-3, mGluR-4, mGluR-6, AMPA or NMDA receptors (IC50 > 10 μM). JNJ 16259685 is an inhibitor of mGluR-1a and mGluR-1b.
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| 应用 |
A non-compeitive antagonist at the mGluR-1
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at 4° C
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| 形态 |
Solid
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| 基本信息 | |
| 密度 |
~1.21 g/cm3 (Predicted)
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| 沸点 |
~502.51° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.60 (Predicted)
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| IC50 |
mGluR-1a: IC50 = 0.55 nM (human); Metabotropic glutamate receptor 1: IC50 = 3 nM (rat); human: IC50 = 73 nM
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| PK值 |
pKb: 2.6 (Predicted)
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| Ki 数据 |
mGlu1: Ki= 0.34 nM
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| 可溶性/溶解性 |
Soluble in ethanol (100 mM), and DMSO (25 mM).
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| MDL |
MFCD08690525
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| PubChem CID |
11313361
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