EPZ015866(GSK591)CAS号： 1616391-87-7分子式： C22H28N4O2分子量： 380.22描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
EPZ015866(GSK591) is a potent, selective PRMT5 inhibitor.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
EPZ-015866,EPZ 015866，GSK-591,GSK 591,GSK3203591,GSK-3203591,GSK 3203591
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| 外观 |
Powder
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| 可溶性/溶解性 |
10 mM in DMSO
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| 生物活性 | |
| 靶点 |
PRMT5
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| In vitro(体外研究) |
In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases.
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分子结构图
