CM-579CAS号： 1846570-40-8分子式： C29H40N4O3分子量： 492.65描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:45 mg/mL (91.34 mM)
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| 生物活性 | |
| 靶点 |
DNMT1:1.5 nM （kd）, DNA methyltransferase:32 nM, DNMT3B:1000 nM, G9a:16 nM, DNMT3a:92 nM
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| In vitro(体外研究) |
CM-579 inhibits DNMT3A and DNMT3B ( IC50s: 92 nM and 1000 nM). The Kd of CM-579 for DNMT1 is 1.5 nM. [1]
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