SC75741CAS号： 913822-46-5分子式： C29H23N7O2S2分子量： 565.67描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
SC 75741
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| 外观 |
white to beige powder
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| 可溶性/溶解性 |
DMSO : 33 mg/mL (58.3 mM)
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| 生物活性 | |
| 靶点 |
NF-κB；p65
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| In vitro(体外研究) |
SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants.
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| In vivo(体内研究) |
SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection.
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分子结构图
