MK-571 sodiumCAS号： 115103-85-0分子式： C26H26ClN2O3S2Na分子量： 537.07描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
MK-571 (L-660711) sodium is a selective, orally active leukotriene D4 receptor antagonist, with Kis of 0.22 and 2.1 nM in guinea pig and human lung membranes.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
L-660711 sodium
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| 外观 |
white to beige powder
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| 可溶性/溶解性 |
DMSO : ≥ 33 mg/mL (61.44 mM)
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| 生物活性 | |
| 靶点 |
CysLT1,MRP1,MRP4,cMOAT
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| In vitro(体外研究) |
L-660,711 inhibited LTD4 binding in guinea pig lung with a Ki value of 0.22±0.15 nM (n=35) and LTD4 binding in human lung with a Ki value of 2.1±1.8 nM (n=29). L660,711 was essentially inactive versus LTC4 binding with IC50 values of 23±11 μM (n=16) and 32 μM (n=1) in guinea pig and human lung, respectively.
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| In vivo(体内研究) |
MK-571 is well tolerated in healthy young men. After oral administration, MK-571 is rapidly JPorbed. The maximum plasma concentration occurring at 1.1-1.5 h at all doses.
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分子结构图
