BMS 195614/BMS 614CAS号： 182135-66-6分子式： C29H24N2O3分子量： 448.5描述纯度储存/保存方法参考文献
| 产品描述 | |
| 描述 |
BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM).1 It antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.2
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at -20℃
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| 参考文献 | |
| 参考文献 |
1.Géhin, M.,Vivat, V.,Wurtz, J.M., et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chemistry & Biology 6(8), 519-529 (1999).
2.Germain, P.,Gaudon, C.,Pogenberg, V., et al. Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists. Chemistry & Biology 16(5), 479-489 (2009). |
分子结构图
