NGP 555CAS号： 1304630-27-0分子式： C23H23FN4S分子量： 406.52描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
NGP 555是γ-secretase的小分子调节剂，在靶向脂质膜的临床前实验中，NGP 555具有大脑渗透性、中枢神经系统活性和特异性。 |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
NGP555
|
| 可溶性/溶解性 |
DMSO ：40 mg/mL (98.39 mM)
Ethanol ：3 mg/mL (7.37 mM) |
| 生物活性 | |
| 靶点 |
(gamma)-secretase
|
| In vitro(体外研究) |
NGP555 potently lowers Aβ42 in cell cultures (9 nM) while increasing shorter forms of Aβ.
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| In vivo(体内研究) |
NGP555 significantly lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post dose, panel B shows that reduction of Aβ cerebrospinal fluid (CSF) levels is significant at 3.75 mg/kg of NGP555 and above, and panel C shows an increase in Aβ38 levels at 15 mg/kg of NGP555 and above. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above (panel D). NGP555-treated Tg mice show a significant protection from decline in performance with >65% less decline (P.
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分子结构图
